Fate/ Outcome/ Disposition/ Consequences of Necrotic tissue

Under exceptional circumstances, the necrotic tissue may remain in the body for some time but ultimately its removal occurs by one of the following mechanisms-

1. Liquefaction by autolysis and heterolysis and then removal of fluid through blood or lymph.   

    This is the most common mechanism for removal of the necrotic tissue. This occurs always     

    for CNS.

2. Liquefaction with cystic accumulation of fluid when the rate of liquefaction is faster than the

    rate of drainage.

3. Liquefaction with abscess formation when the necrotic tissue is invaded by pyogenic  

    bacteria.

4. Encapsulation without liquefaction when there is little moisture in the necrotic tissue. This

    necrotic tissue causes accumulation of inflammatory cells and proliferation of fibrous   

    connective tissue.

5. Desquamation or sloughing off when the necrosis occurs on external or internal epithelium

    lining of genital tract, GIT, respiratory tract.

6. Replacement of necrotic tissue by scar tissue formation, e.g., in kidney, liver.

7. Dystrophic calcification by deposition of calcium salts in the dead tissue.

8. Gangrene formation.

    Gangrene is a condition in which necrotic tissue is invaded by saprophytic and usually  

    putrefactive bacteria.

9. Atrophy of the organ.

    Atrophy is the shrinkage or reduction of an organ or a tissue to less than its former normal    

    size.

10. Regeneration

     It is the process in which the necrotic tissue is replaced by the living cells. It is the fortunate    

     outcome of necrosis. Living cells are produced by mitosis of the remaining living cells.


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