Biotransformation of drugs

The chemical alteration of drugs in the body 

  • To render nonpolar lipid soluble compounds into polar water soluble compounds to enhance their excretion from the body
  • Intended to protect body from the foreign substances by making them less toxic and easily excreted
  • Primary site - liver
  • Other important sites are kidney, intestine, lungs and plasma
  • General Pattern of biotransformation - biphasic
Biotransformation

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